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Huntington's Disease Research: Shutting down the mutant gene – HudsonAlpha Institute for Biotechnology
Frontiers | Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases
A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity | PLOS Genetics
Therapeutic approaches for the treatment of HD and other CAG repeat... | Download Scientific Diagram
Molecular genesis of Huntington's disease, illustration. Expansion of the CAG trinucleotide sequence in the htt gene causes production of mutated Huntingtin protein leading to neurodegeneration, atrophy of brain basal ganglia, involuntary movements
A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease: Molecular Therapy - Nucleic Acids
The importance of CagA protein in Helicobacter Pylori infection
The expanded CAG repeat in the huntingtin gene as target for therapeutic RNA modulation throughout the HD mouse brain | PLOS ONE
Mechanisms of RNA-induced toxicity in CAG repeat disorders | Cell Death & Disease
Huntington's disease: prevention and current innovations in treatment - Personalize My Medicine
IJMS | Free Full-Text | Decreased Interactions between Calmodulin and a Mutant Huntingtin Model Might Reduce the Cytotoxic Level of Intracellular Ca2+: A Molecular Dynamics Study
Discovery of a potent small molecule inhibiting Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein | Scientific Reports
Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS: Molecular Therapy - Nucleic Acids
In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease - ScienceDirect
Frontiers | The MID1 Protein: A Promising Therapeutic Target in Huntington's Disease
An outline of early steps by which the trinucleotide (CAG) repeat... | Download Scientific Diagram
HIV drug could be repurposed to prevent toxic protein build-up in dementia and Huntington's disease, University of Cambridge research suggests